This study unfolds against the dynamic backdrop of digital transformation in education, tackling the pressing challenges of homogenization and broad-spectrum methodologies in nurturing learning capabilities within application-oriented higher education institutions. A three-tiered implementation framework that encompasses “data governance—intelligent diagnosis—targeted intervention” have been meticulously crafted. By integrating artificial intelligence technology with pioneering educational paradigms, a meticulously crafted pathway for talent cultivation has been presented: at the data governance level, the diverse data sources have been amalgamated to construct dynamic and comprehensive student profiles; at the intelligent diagnostic level, a stratified early warning systems and models for potential identification has been developed; at the targeted intervention level, the innovative mechanisms that foster collaborative integration between industry and education alongside blended learning approaches has been devised. Specifically, within the realm of targeted intervention strategies, the tiered response frameworks have been crafted through synergistic collaborations between industry and academia, alongside innovative blended learning modalities. The approach encompasses the establishment of three distinct levels of interventions: academic crisis management, potential enhancement initiatives and specialized support for unique groups. Furthermore, a comprehensive system that aligns job competencies with curricular content while employing an intelligent grouping mechanism designed to optimize team collaboration efficiency are committed to be developed. Practical applications reveal that this pathway significantly improves the efficiency of identifying academic crises, while concurrently expediting students transition into professional roles. Furthermore, it cultivates students practical skills and adaptability to job requirements, while innovating ideas and methodologies for talent cultivation in application-oriented higher education institutions. This research not only furnishes concrete practical guidance for application-oriented higher education institutions navigating digital transformation but also offers novel concepts and strategies for building a strong educational nation.