Abundant in knowledge resources, knowledge talents and scientific-research technologies, college town library association is an important part of education, scientific research and industrial ecosystem. Knowledge ecological resource system, which is considered as an advanced form of knowledge management, is concerned with symbiotic relationship between knowledge subject and knowledge resources, technology and environment. In a wisdom library environment, knowledge ecological resource system of the college town library association will improve construction and sharing of knowledge resources, improve the comprehensive strength of the college town association, and speed up the integrated development of regional knowledge economy.