Patent operation in colleges and universities has attracted more and more governmental attention, but from the current situation of operation, the effect is far from ideal. There are still a series of problems, such as the asymmetry of scientific research information, the disconnection of market demand, the low conversion rate, the lack of operation talents and so on. The integration of universities and local development opens a new way of thinking for promoting the development of patent operation in colleges and universities. Starting from the needs of the development of schools and enterprises, the innovation mechanism of school-enterprise cooperation to promote patent operation should be established, the integration of schools and local areas should be used to cultivate professional talents, and the deep integration of technologies, resources, mechanisms and talents should be strengthened to promote the development of the operation of colleges and universities.